In light of these preclinical results, standard and specialized neurologic and audiologic safety assessments and adjudication of events were conducted across the ALLEGRO program.25 Clinical data from the integrated safety analysis, including adjudicated events deemed possible neurologic or audiologic events of interest, showed no evidence of neurotoxicity with ritlecitinib treatment.25 Most AEs associated with neurologic events of interest such as dysesthesia, hyperesthesia, hypoesthesia, and paresthesia were mild in severity, considered by investigators to be unrelated to treatment, and resolved spontaneously.25 In a placebo-controlled phase 2a clinical safety study specifically evaluating potential neurologic/neuroaudiologic effects of ritlecitinib in adults with AA using BAEP assessments and intraepidermal axon histology, no notable effects were observed on nerve fiber counts, intraepidermal axon inflammation, or integrity of the human brainstem auditory pathway as assessed by BAEP.25 These data support that the dog finding of axonal dystrophy is not clinically relevant in humans.25 Laboratory assessments Ritlecitinib was associated with early, dose-dependent decreases in lymphocyte counts
Functions of Astrocytic GSH for Neurons and the Brain Astrocytes have a high GSH content which enables these cells to efficiently perform GSHdependent processes, such as the reduction of potential harmful peroxides and removal of xenobiotics (Figure 2) (Dringen et al
Description: GHK-Cu is a synthetic copper peptide complex consisting of the tripeptide glycyl-L-histidyl-L-lysine chelated to a copper (II) ion
Lim AS, Kowgier M, Yu L, Buchman AS, Bennett DA
